LY 293646
NU7026
CAS: 154447-35-5
Molecular Formula: C17H15NO3
LY 293646 - Names and Identifiers
| Name | NU7026 |
| Synonyms | CS-595 NU7026 NU 7026 NU-7026 LY293646 LY 293646 2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one |
| CAS | 154447-35-5 |
LY 293646 - Physico-chemical Properties
| Molecular Formula | C17H15NO3 |
| Molar Mass | 281.31 |
| Density | 1.330 |
| Melting Point | 267-269 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
| Boling Point | 459.9±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO |
| Appearance | solid |
| Color | tan |
| pKa | 0.49±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD06798345 |
| In vitro study | NU7026 dose-dependently enhances ionizing radiation-induced cytotoxicity in both V3YAC and PARP-1 +/+ cells. NU7026 completely abolished the recovery of potentially lethal injury in growth-arrested cells. NU7026 inhibited 56% of DNA DSB repair in the V3 YAC cell line. In K562 cells, NU7026 (10 μm) enhanced the growth inhibition of idarubicin,daunorubicin,doxorubicin,etoposide,mAMSA, and mitoxantrone, with PF50 values in the range of approximately 19 (vs. mAMSA). To 2 (to idarubicin). NU7026 (10 μm) also enhanced etoposide growth inhibition in leukemic cells with a PF50 value of 10.53. NU7026 (10 μm) enhanced etoposide-induced G2 phase arrest in K562 cells. NU7026 enhances the toxicity of topo II, including inhibition of non-homologous end joining and G2/M checkpoint blockade. In CH1 human ovarian cancer cells, NU7026 (10 μm) exposure for 4 hours in combination with 3 Gy radiation is necessary for significant radiosensitization. In the CLL cell line (I83) and primary CLL-lymphocytes, NU7026 (< 10 μm) had synergistic cytotoxic activity with chlorambucil at the nontoxic dose of nu7026. NU7026 (10 μm) increased chlorambucil-induced G(2)/M phase arrest in I83 cells. In I83 cells, NU7026 (10 μm) enhanced chlorambucil-induced gamma H2AX throughout the cell cycle. NU7026 (10 μm) increased chlorambucil-induced apoptosis in the I83 cell line. NU7026 (55 μm) resulted in significant induction of telomere fusion in MEFs with p53 deletion and less telomeric fusion in MEFs with p53 and Ligase IV double deletion. |
| In vivo study | NU7026(20mg/kg, I. v.) has a rapid plasma clearance (0.108/hr) in mice, which is largely due to extensive metabolism. The bioavailability of NU7026 after intraperitoneal (I. p.) or oral administration at a dose of 20 mg/kg was 20 and 15%, respectively. |
LY 293646 - Risk and Safety
| WGK Germany | 3 |
LY 293646 - Introduction
NU7026, also known as 4H-naphthopyrone anthracene (Carbazolequinone anthracenyl) is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: NU7026 is a solid compound.
-Solubility: It is soluble in organic solvents.
-Chemical properties: Due to the existence of its morpholino group and ketone group, it shows some special properties in chemical reactions.
Use:
- NU7026 has potential applications in the field of optoelectronic devices, such as organic light-emitting diodes (OLED), organic solar cells, etc.
-It can also be used as an intermediate in organic synthesis and can be used to synthesize other compounds.
Preparation Method:
- NU7026 preparation method is more complex, generally need to start from more starting material, through a series of chemical reactions to synthesis. The specific synthetic route will vary depending on the purpose of the study and the experimental conditions.
Safety Information:
- NU7026 generally does not have a clear toxicity under regular experimental conditions, but as a chemical, it is still necessary to comply with regular safety procedures and laboratory safety instructions.
-During use or storage, avoid contact with flammable materials and keep away from fire sources.
-Appropriate personal protective equipment such as lab gloves, goggles and lab coats should be used in all cases.
Please note that this information is for reference only. It should be operated and used according to specific experimental conditions and laboratory requirements, and relevant safety regulations should be observed. Use caution when using chemicals and consult a professional if necessary.
Nature:
-Appearance: NU7026 is a solid compound.
-Solubility: It is soluble in organic solvents.
-Chemical properties: Due to the existence of its morpholino group and ketone group, it shows some special properties in chemical reactions.
Use:
- NU7026 has potential applications in the field of optoelectronic devices, such as organic light-emitting diodes (OLED), organic solar cells, etc.
-It can also be used as an intermediate in organic synthesis and can be used to synthesize other compounds.
Preparation Method:
- NU7026 preparation method is more complex, generally need to start from more starting material, through a series of chemical reactions to synthesis. The specific synthetic route will vary depending on the purpose of the study and the experimental conditions.
Safety Information:
- NU7026 generally does not have a clear toxicity under regular experimental conditions, but as a chemical, it is still necessary to comply with regular safety procedures and laboratory safety instructions.
-During use or storage, avoid contact with flammable materials and keep away from fire sources.
-Appropriate personal protective equipment such as lab gloves, goggles and lab coats should be used in all cases.
Please note that this information is for reference only. It should be operated and used according to specific experimental conditions and laboratory requirements, and relevant safety regulations should be observed. Use caution when using chemicals and consult a professional if necessary.
Last Update：2024-04-09 21:04:16
Supplier List
Product Name: NU7026 Visit Supplier Webpage Request for quotation
CAS: 154447-35-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 154447-35-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: NU7026 Visit Supplier Webpage Request for quotation
CAS: 154447-35-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 154447-35-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History